Updated: September 14 2013
What Is It?CDP-choline (cytidine diphospho-choline), also called citicholine and cytidine 5'-diphosphocholine, is a nootropic or psychostimulant compound.
CDP-choline can be synthesized from choline in the human body. [11]
Bioavailability
CDP-choline is water soluble. [9]
What Does Human Research Studies Say?
1. Increases attention; small effect. [1]
2. Increases memory (cognition); small effect; seen in otherwise healthy older adults. [2-3]
3. Decreases cognitive decline; small effect. [2]
4. Increases visual acuity (vision protection); small effect; seen in persons with glaucoma. [4]
5. Decreases cocaine addiction; small and unreliable effect. [5-7]
6. Decreases blood pressure (BP); small effect; in older adults; see the heading about side effects. [2]
7. Decreases appetite; small effect; usually with higher doses (2,000mg daily). [12]
Conclusion
May increase memory, attention, visual acuity, and decrease cognitive decline!
Verdict: May be added to your supplement stackRecommended Dosage (Used in the Studies)
250mg to 1000 mg / 2 times daily (separated by 8-12 h); can be take at once (500-2,000 mg)
Where Can You Buy This Supplement?
1. For UK/USA/EU click: 10 grams (10,000 mg) CDP-choline CleverMinds Powder for £12.49
2. For UK/USA/EU click: 20 grams (20,000 mg) CDP-choline CleverMinds Powder for £20.00
Side Effects of This Supplement
1. Usually well tolerated in most individuals; 2000 mg / daily have been observed without severe side effects. [10]
2. CDP-choline may cause insomnia, headache, diarrhea, blood pressure differences nausea, blurred vision, and chest pain. [8,10]
Other Names for This Supplement
5'-Cytidine diphosphate choline, CDPC, CDP Choline, CDP-Choline, Citicholine, Citicolina, Cytidine 5-Diphosphocholine, Cytidine 5'-diphosphocholine, Cytidine (5') diphosphocholine, Cytidine Diphosphate Choline, Cytidine Diphosphocholine, Cytidinediphosphocholine.
References
1. Improved Attentional Performance Following Citicoline Administration in Healthy Adult Women
2. Citicoline improves memory performance in elderly subjects
3. Citicoline improves verbal memory in aging
4. Evidence of the neuroprotective role of citicoline in glaucoma patients
5. Short-term treatment with citicoline (CDP-choline) attenuates some measures of craving in cocaine-dependent subjects: a preliminary report
6. Effects of daily treatment with citicoline: a double-blind, placebo-controlled study in cocaine-dependent volunteers
7. A randomized, placebo-controlled trial of citicoline add-on therapy in outpatients with bipolar disorder and cocaine dependence
8. WebMD - Citicoline
9. A rapid LC-ESI-MS/MS method for the quantitation of choline, an active metabolite of citicoline: Application to in vivo pharmacokinetic and bioequivalence study in Indian healthy male volunteers.
6. Effects of daily treatment with citicoline: a double-blind, placebo-controlled study in cocaine-dependent volunteers
7. A randomized, placebo-controlled trial of citicoline add-on therapy in outpatients with bipolar disorder and cocaine dependence
8. WebMD - Citicoline
9. A rapid LC-ESI-MS/MS method for the quantitation of choline, an active metabolite of citicoline: Application to in vivo pharmacokinetic and bioequivalence study in Indian healthy male volunteers.
10. Therapeutic applications of citicoline for stroke and cognitive dysfunction in the elderly: a review of the literature.
11. Glycerophosphocholine catabolism as a new route for choline formation for phosphatidylcholine synthesis by the Kennedy pathway.
12. Citicoline affects appetite and cortico-limbic responses to images of high-calorie foods
11. Glycerophosphocholine catabolism as a new route for choline formation for phosphatidylcholine synthesis by the Kennedy pathway.
12. Citicoline affects appetite and cortico-limbic responses to images of high-calorie foods
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