Updated: September 2 2013
What Is It?Piracetam (2-oxo-1-pyrrolidine acetamide) is a nootropic and belongs to the group of racetams. Piracetam is a cyclic derivative of GABA.
What Is it Used For?
Piracetam is used to control involuntary movements mainly in myoclonus.
Some of the trade names include: Breinox, Dinagen, Lucetam, Nootropil, Nootropyl, Oikamid
Where Can It Be Found?
Piracetam is not found naturally. It was synthesized in 1964 by scientists at the Belgian pharmaceutical company UCB led by Dr Corneliu E. Giurgea.
1. Reduction in the rate of cognitive decline[1,2,3,4,5,6]
2. Significant reduction of breath holding spells in infants[7,8,9]
3. Non-significant (very small) increase in backwards memory recall[6,10]
Do You Need This Supplement?
Piracetam appears to increase cognitive capacities in elderly persons by reducing the rate of cognitive decline but more research is needed in healthy persons.
Verdict: Not essential in your supplement stack for muscle growthRecommended Dosage (Used in Research)
1. Breath holding spells: 40-100 mg/kg with the lower end of the range (40-50mg/kg) usually being used.
2. Youth with Dyslexia: 40-100 mg/kg.
3. Adults: 1200-4800 mg/daily. The largest effective dose appears to be 1600mg of Piracetam taken thrice a day in divided doses to total 4800mg overall.
Where Can You Buy This Supplement?
Amazon.com
Side Effects of This Supplement
Diarrhea, weight gain, somnolence, insomnia, nervousness, depression, hyperkinesia, rash
Pharmacology
Piracetam's mechanism of action is not fully understood. Piracetam increases glucose and oxygen consumption in brains which precedes cognitive improvement[11,12]
References
1. Clinical efficacy of piracetam in cognitive impairment: a meta-analysis
2. Drug therapy and memory training programs: a double-blind randomized trial of general practice patients with age-associated memory impairment
3. Long-term and high-dose piracetam treatment of Alzheimer's disease
4. On the dose-effect relationship in the therapy with piracetam (author's transl)
5. A double blind investigation of piracetam (Nootropil) vs placebo in geriatric memory
6. The effects of oxiracetam (ISF 2522) in patients with organic brain syndrome (a double-blind controlled study with piracetam)
7. Piracetam in severe breath holding spells
8. Double-blind, placebo-controlled trial on the effect of piracetam on breath-holding spells
9. Clinical efficacy of piracetam in treatment of breath-holding spells
10. Increase in the power of human memory in normal man through the use of drugs
11. Effect of Piracetam on electrocorticogram and local cerebral glucose utilization in the rat
12. Effect of piracetam on cerebral glucose metabolism in Alzheimer's disease as measured by positron emission tomography
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| 2D structure of nootropic piracetam |
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| 3d Model of Piracetam |
| © Muscular Science 2013 |
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