Pterostilbene

Wednesday, 25 September 2013


Updated: September 25 2013
What Is It?
Pterostilbene (trans-3,5-dimethoxy-4-hydroxystilbene) is a stilbenoid compund that belongs to the group of phytoalexins. It is related to resveratrol (it is a double-methylated derivative of resveratrol). Pterostilbene is supposed to have anti-cancer, anti-hypercholesterolemia, anti-diabetic, anti-dementia, and anti-hypertriglyceridemia properties[1,2]

Pterostilbene - chemical formula

Sources of Pterostilbene
Pterostilbene is found naturally in found in blueberries, grapes, peanuts (Arachis hypogaea), and in Pterocarpus marsupium (Indian Kino Tree).

Pharmacology
1. Bioavailability: 67%-94%; pterostilbene is better absorbed following oral ingestion and is more potent  (antioxidant and anticancer) than resveratrol. [3,7,8]
2. Half-life: 78 - 104 minutes. [3,7,8]

What Does Human Research Studies Say?
Lack of studies.

What Does Animal/Tissue Culture Research Studies Say?
1. Increase in life expectancy (longevity) in yeast and mice. [9,10,11]  
2. Decreases neuroinflammation in mice and tissue culture of microglia[12,13]  

Conclusion
Well, creatine works and is a very good supplement in those who respond to it.
Verdict: May be added to your supplement stack
Recommended Dosage (Used in the Studies)
1. For anti-diabetic and anti-hypertriglyceridemia properties: 215 mg to 730 mg
2. For anxiolytic properties:  5.5 mg to 18 mg


Where Can You Buy This Supplement?

Amazon.com

Side Effects of This Supplement

1. Pterostilbene has low toxicity profile. [5-6]  
2. More rare: cardiomyopathy, dehydration, diarrhea, hypertension, ischemic stroke, muscle cramping, nausea, renal dysfunction, rhabdomyolysis, seizures, weight gain

References

1. A new class of phytoalexins from grapevines.
2. Pterostilbene Monograph3. Pharmacokinetics, oral bioavailability, and metabolic profile of resveratrol and its dimethylether analog, pterostilbene, in rats.
5. Dietary administration of high doses of pterostilbene and quercetin to mice is not toxic.
6. Analysis of safety from a human clinical trial with pterostilbene.
7. Pharmacometrics of pterostilbene: preclinical pharmacokinetics and metabolism, anticancer, antiinflammatory, antioxidant and analgesic activity.
8. Association between pterostilbene and quercetin inhibits metastatic activity of B16 melanoma.
12. Stilbenes and Anthocyanins Reduce Stress Signaling in BV-2 Mouse Microglia.
13. Effects of resveratrol and its derivatives on lipopolysaccharide-induced microglial activation and their structure-activity relationships.

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